Maggie Q’s ActivatedYou Essential Skin Food Prep Your Skin for Summertime from the Inside Out

With summer approaching, increased exposure to sunlight is inevitable – meaning extra precautions need to be taken for the health of our skin. ActivatedYou founder Maggie Q encourages you to properly prepare for summer by nourishing your skin to help avoid further damaging effects. Ultraviolet rays break up collagen, which makes up 80% of your skin, so Maggie recommends always applying clean or non-toxic SPF products and minimizing direct sun exposure for long periods of time.

To further support  the skin’s health, Maggie recommends taking collagen-supporting supplements like ActivatedYou Essential Skin Food, to help support  your skin texture from the inside out. ActivatedYou Essential Skin Food is a dietary supplement that encourages healthy collagen production for firmer, plumper-looking skin. Studies show that with the use of “anti-aging products or treatment, collagen production can be boosted, or its natural loss can be slowed down. Anti-aging treatments are also necessary to help reduce the appearance of fine lines, wrinkle, acne and it also helps in making the skin firm”.*

ActivatedYou Essential Skin Food is a dietary supplement that encourages healthy collagen production for firmer, plumper-looking skin.

ActivatedYou Essential Skin Food is a collagen support supplement designed to support  the overall appearance of skin texture and minimize the look of sagging and dull skin. As we age, our natural collagen is depleted and breaks down faster due to sun exposure. This groundbreaking formula contains zero animal-based collagen and is 100% plant-based, unlike many collagen support supplements on the market.

ActivatedYou Essential Skin Food blends minerals, plant-based vitamins, essential amino acids, and herbal extracts to provide the most powerful benefits of support collagen for strong tissue and hair, healthy nails for firmer, plumper-looking skin. These nourishing compounds are the perfect way to help encourage a renewed and energized complexion and fight skin-damaging free radicals.*

ActivatedYou Essential Skin Food Key Ingredients

  • Dermaval™: A natural collagen-booster that uses phytonutrient compounds like pomegranate extract, camu camu, coffeeberry, and quercetin to help fight the breakdown of elastin in the body and support the elasticity and firmness of the skin.†*
  • Vitamin C: A natural antioxidant that helps fight off free radicals that damage the skin, to promote more radiant and bright-looking skin.†*
  • Amino Acid Complex: contains Lysine and L-Proline, building blocks of collagen, that work together to help tighten and plump skin’s appearance over time.†* 
  • Cosmythic™: An elixir containing polyphenols that help ‘energize’ old cells responsible for collagen production, for more youthful-looking skin.†*

*All individuals are unique. Your results can and will vary.

ActivatedYou Essential Skin Food can be purchased on the ActivatedYou website for $69.95 with a 90-day money-back guarantee.

Breasts: Normal, Medically Worrisome and Things to be Corrected

Breasts come in all shapes and sizes and there is infinite variety in the human experience. Beyond their physiological function of providing nourishment for babies, however, breasts occupy a unique place in the cultural ether and many women wonder and worry about whether or not they deviate from ‘normal’. “Unfortunately, we are often bombarded by an air-brushed, unrealistic image of what constitutes the normal breast”, says Dr. Constance M. Chen, plastic surgeon and breast reconstructive specialist. “Even as young women mature and become comfortable with their own unique physical characteristics, there are any number of variations that may trigger questions about what is normal, what is medically worrisome, and what can be ‘corrected”.

There is no normal breast size or shape. Nor is there a normal nipple size or color. Nipples and the areolae that surrounds them might be large or small, pale or dark, might match skin tone or might not. Small bumps on the areola are lubricating glands and are completely normal. “Chances are that whatever is causing concern is a completely normal variation”, says Dr. Chen. “Here are some common variations in normal breasts along with recommendations on when to see a doctor”.

Breasts that don’t match: Very few women have perfectly symmetrical breasts. One breast may be larger, shaped differently, or positioned differently than the other. Differences in size up to 20% are normal and are particularly common in teenagers whose breasts may develop at different rates. Hormonal changes associated with ovulation, pregnancy, and breastfeeding that cause changes in breast size may also cause asymmetry. Breasts that differ by more than a cup size and asymmetry unrelated to pregnancy that develop suddenly overnight, however, should be evaluated by a doctor to rule out a medical problem.

Hair on or around the nipples: “Human beings have hair all over their bodies”, says Dr. Chen. “Sometimes human hair is thin and clear and sometimes it’s thicker and darker. It is quite common for women to have darker visible hair around their nipples”. A few hairs is nothing to worry about but denser growth might be indicative of a hormonal imbalance or other issue. The best way to avoid infection when removing hair around the nipples is with small scissors.

Inverted nipples lie flat against the areola or turn inward instead of protruding. They occur in either one or both breasts and may be present from birth or develop later in life. “As many as 10% of women may have one or both nipples inverted”, says Dr. Chen. “They are not generally a cause for concern and require treatment only if they interfere with breastfeeding, if there is an underlying medical condition that must be addressed, or to satisfy aesthetic preferences”. There are several treatment options for inverted nipples, most of them temporary; surgery is the only permanent treatment. Sudden changes, however, may indicate problems that should be evaluated by a physician.

An extra nipple, also called a supernumerary nipple, occurs in 3-5% of people, both men and women, and seldom needs to be removed for any but cosmetic reasons. It may go undetected, mistaken for a mole, and if it occurs alone, it can be removed in a simple procedure much like removing a mole. If it occurs with underlying breast tissue, it should be monitored for changes as the breasts are and removal is much like a mastectomy.

“While these variations are mostly common and benign, there are changes in the breasts that do require examination”, says Dr. Chen. “While being conscientious about regular mammograms and self-exams checking for lumps, women should also be alert to anything out of the ordinary that persists beyond a menstrual cycle. In particular, there are indications that require medical evaluation”.

  • Discharge from the nipples: Fluid can commonly be expressed from the nipples of pre-menopausal women, particularly those who have given birth or nursed a baby in the last year or two, but spontaneous discharge, particularly if bloody or yellow, should prompt a visit to a doctor.
  • Skin changes: The skin on the breasts can be affected by common skin conditions like eczema and psoriasis, and from irritation by clothing or other contact, but some skin changes might have a more serious cause. These include ulceration, scaliness, crusting, dimpling, and redness that is not from an identifiable source.
  • Nipple inversion that occurs suddenly in an adult could be a sign of trouble.

Dr. Chen reminds us that the soft tissue that we think of as a breast is actually a mammary gland, a complex system of fat cells and ducts that produce milk and deliver it to a nursing infant via the nipple. “Breasts are remarkable”, she says. “They fulfill vital functions, undergo changes at different times in a woman’s life, and are as variable as every other part of the human anatomy. Most of these variations are completely normal but any woman with a question shouldn’t hesitate to discuss her concerns with her doctor”.

About Dr. Constance M. Chen

Constance M. Chen, MD, is a board-certified plastic surgeon in New York City with special expertise in the use of innovative natural techniques to optimize medical and cosmetic outcomes for women undergoing breast reconstruction. She is Clinical Assistant Professor of Surgery (Plastic Surgery) at Weill Cornell Medical College and Clinical Assistant Professor of Surgery (Plastic Surgery) at Tulane University School of Medicine.

Dr. Chen is frequently invited to lecture nationally and internationally on new advancements in breast reconstruction and the surgical treatment of lymphedema. She is the author of three books, five book chapters, and fifty journal articles. She has also won numerous awards for her work in plastic and reconstructive surgery at the local, regional, and national levels.

Dr. Chen has developed a reputation in the community for the personalized attention that she devotes to her patients. She is committed to aesthetic restoration of the breast and body, and enjoys helping her patients achieve overall well-being. At the end of the day, there is nothing more important to her than the joy she hopes to bring to her patients’ lives. Come into the beautiful world of Dr. Constance M. Chen.

Breast Reconstruction Specialist Dr. Constance M Chen Offers Tips on Restoring Breast Sensation After Mastectomy

Each year in the United States, more than 100,000 women have mastectomies. Advances in surgical techniques today offer women the hope of a soft, warm breast that may look similar and feel much like her original breast, especially if she undergoes natural tissue breast reconstruction. As a result, more and more women now choose breast reconstruction, either at the time of the mastectomy or later. However, in some cases, women who undergo breast reconstruction learn that the natural “look and feel” of her restored breast actually relates to how the breast will look and feel to someone else. Some women report that their reconstructed breasts do not feel at all natural to her and moreover that the reconstructed breast lacks all feeling and is completely numb to touch and sexual arousal.

The prevalence of social media and zoom conferences has led some women to be more self-conscious about how they look. While our capability to reconstruct a woman’s breast after a mastectomy has come a long way, the emphasis has been on rebuilding her appearance, with less focus on how she feels. In fact, after mastectomy, many women discover that their breasts are numb – a reality for which they were unprepared. The positive news today is that new techniques in breast reconstruction allow specially trained surgeons to reconnect nerves with the possibility of restoring sensation.

Dr. Constance M Chen, plastic surgeon and breast reconstruction specialist

Why the loss of sensation. In a mastectomy the nerves that provide feeling to the breast and nipple are cut, resulting in a loss of sensation in the remaining skin, regardless of whether or not the woman undergoes breast reconstruction. In the case of breast reconstruction using implants, the artificial breast implant may actually form a physical barrier that prevents nerves from growing through it to reach the skin. However, with natural tissue breast reconstruction, microsurgeons can suture together nerves from a woman’s own tissue to create a new sensate breast. In these cases, rejoining blood vessels and nerves allows them to grow through the transferred tissue to reach the skin and increase the potential return of sensation.

There are different types of sensation – deep pressure, light touch, pain, and temperature – and they each come back at different rates. Deep pressure sensation usually returns most quickly and temperature most slowly. Moreover, regenerated nerves can take months or even years to reach the skin, and the quality of sensation is variable. “Since nerve growth is slow and the return of sensation is not ensured, not all surgeons prioritize reconnecting the nerves to restore sensation”, says Dr. Chen. “However, taking the time in surgery to carefully repair the nerves can result in the return of feeling and improved sensation.” Innovative microsurgical techniques that use neural tubes and nerve grafts have provided some patients with excellent sensation and even erectile function of the nipple.

“Restoring sensation is on the frontline in breast reconstruction”, Dr. Chen concludes. “Sensory restoration can help a woman feel more normal after mastectomy. Each woman will have a unique experience and result, but it is important for surgeons to do their best to restore a woman’s body as fully as possible to help her regain her health and sense of self”.

About Dr. Constance M. Chen

Constance M. Chen, MD, is a board-certified plastic surgeon in New York City with special expertise in the use of innovative natural techniques to optimize medical and cosmetic outcomes for women undergoing breast reconstruction. She is Clinical Assistant Professor of Surgery (Plastic Surgery) at Weill Cornell Medical College and Clinical Assistant Professor of Surgery (Plastic Surgery) at Tulane University School of Medicine.

Dr. Chen is frequently invited to lecture nationally and internationally on new advancements in breast reconstruction and the surgical treatment of lymphedema. She is the author of three books, five book chapters, and fifty journal articles. She has also won numerous awards for her work in plastic and reconstructive surgery at the local, regional, and national levels.

Dr. Chen has developed a reputation in the community for the personalized attention that she devotes to her patients. She is committed to aesthetic restoration of the breast and body, and enjoys helping her patients achieve overall well-being. At the end of the day, there is nothing more important to her than the joy she hopes to bring to her patients’ lives. Come into the beautiful world of Dr. Constance M. Chen.

The Most Important Advice for Plastic Surgery Patients is to Choose their Doctor Carefully, says Dr. J Plastic Surgery

The Beverly Hill-based plastic surgeon comments on a recent article that, while skin care tips are helpful and good aftercare is a must for recovering patients, the best and only way to ensure an outstanding recovery is to select an outstanding physician.

A February 1 article on Allure compiles suggestions from experts on skincare after a rhinoplasty (aka, a nose job). Tips in the article include being careful when washing the area around the nose, moisturizing regularly, and using sunscreen to protect skin from ultraviolet rays. Beverly Hills plastic surgeon Payam Jarrah-Nejad, M.D., F.I.C.S., F.A.C.S., known more informally to his patients and colleagues as Dr. J, says that a good plastic surgeon will monitor patients postoperative progress and provide them with all of the self-care information they need.

While it’s crucial to practice good self-care following any surgery, the most important step of all in a facial or body procedure is the selection of the best possible plastic surgeon for the job.

Dr. J notes that, while it’s crucial to practice good self-care following any surgery, the most important step of all in a facial or body procedure is the selection of the best possible plastic surgeon for the job before surgery. He adds that it’s essential that patients limit their search to board-certified plastic surgeons. This is because not all doctors who are legally allowed to perform rhinoplasties and other procedures have undergone the two years of additional training required to call themselves plastic surgeons, says Dr. J. Moreover, board certification proves that a surgeon’s knowledge and skills have met the rigorous standards of the American Society of Plastic Surgeons. He adds that it’s also essential to account for the aesthetic X-factor that separates merely competent plastic surgeons from those likely to produce superb results.

Dr. J, who is double-board certified in both plastic surgery and general surgery, adds that one way to see if a doctor has mastered the art, as well as the science, of plastic surgery is to examine their past outcomes. For example, Dr. J’s rhinoplasty results can be seen on his online gallery. The doctor notes that looking at before-and-after pictures can help a patient imagine the kind of outcomes that might be possible in their own case.

Returning to the topic of recovery following a rhinoplasty or other procedure, Dr. J says that he has worked hard over the years to developing highly advanced techniques for minimizing patient recovery times on all of his procedures. He adds that patients who want to benefit from a recovery that is both successful and more rapid can help ensure both is by insisting on a board-certified plastic surgeon with a proven track record of outstanding outcomes.

About Dr. Payam Jarrah-Nejad, Dr. J

Payam Jarrah-Nejad, MD, FICS, FACS is a double board certified Beverly Hills Plastic Surgeon. Nicknamed Dr. J by his patients and staff, he holds certifications from both the American Board of Plastic Surgery and the American Board of Surgery. Dr. J is also an active member of the American Society of Plastic Surgeons and a Fellow of The American College of Surgeons.

Dr. J first started his medical career during an internship he held in NYU. It was during this time that he also began working with hospitals around the New York area. It was in New Jersey that he completed his training and served as Chief Resident at Morristown Memorial Hospital.

Certified by the American Board of Surgery and the American Board of Plastic Surgery, Dr. Jarrah-Nejad received a fellowship at Beth Israel Medical Center in New York City to specialize in hand surgery. The fellowship was under the guidance of Dr. Charles P. Melone which was a big influence on the young doctor. It was during his training at Wayne State University, Detroit Medical Center in Michigan that Dr. J found his true calling working with many well-known plastic surgeons.

Years later, practicing as a board-certified plastic surgeon, Dr. J still uses the same techniques he learned in his training in his frequent operation on the face and body. He is greatly admired by his staff and patients who happily contribute positive testimonials to his website.

Dr. J is known throughout the Los Angeles Area medical community as well as beyond it, for his record of outstanding outcomes and his engaging, patient-friendly personality. He has published a wide range of papers in many prestigious scientific and medical journals and has presented his research to local, regional and national symposia.

Finally, Dr. J has performed pro-bono surgery in several countries as part of humanitarian efforts helping children with congenital anomalies. He works side by side with charitable organizations devoted to providing needy children around the world with free plastic surgeries to repair such issues as cleft lips and palates.

Come into the beautiful world of Dr. J.

Board-Certified Plastic Surgeon Dr. Constance M Chen on Why Breast Implants are Removed

Over 400,000 women in the United States receive breast implants each year. Three quarters receive breast implants for cosmetic breast augmentation, while the other one quarter receive breast implants to reconstruct a breast lost to cancer. According to the implant manufacturers, about 50% of women with breast implants undergo another surgery to revise, replace, or remove their breast implants within 7 years. Since breast implant problems are common, on October 27, 2021, FDA strengthened breast implant risk communication to help those considering breast implants make informed decisions.

According to the implant manufacturers, about 50% of women with breast implants undergo another surgery to revise, replace, or remove their breast implants within 7 years.

For starters, the FDA now requires a black box warning on all breast implants to let people know that they are not considered lifetime devices and carry risks. In addition, patients are required by law to initial and sign an extensive patient decision checklist that outlines many potential risks and complications, including Breast Implant Illness and Breast Implant Associated Anaplastic Large Cell Lymphoma. There are also updated silicone gel-filled breast implant screening recommendations, device descriptions with a list of specific materials used to make breast implants, and a patient device card. Finally, the FDA released updated information on the status of breast implant manufacturer post-approval studies.

Board-certified plastic surgeon and breast reconstruction specialist Dr. Constance M. Chen comments that there are many medical and cosmetic reasons that women have implants removed. “In some cases the implants basically fail and must be removed for the health of the woman. In other cases, women realize that they don’t have to live with implants that are not comfortable for them. For example, women with cosmetic breast implants sometimes reach a new stage in their lives in which they no longer feel that breast implants fit their lifestyle anymore.”

Breast implants don’t last forever

Implants aren’t expected to last forever. Most implants have a ten-year warranty although many are removed before the warranty period is over. The risks only increase with time.

Implants are foreign material, and as such, they elicit a natural response in which the body creates a barrier of scar tissue around the implant to wall it off and protect any foreign substance from penetrating other parts of the body. In some cases this barrier, or capsule, is soft, flimsy and not noticeable. In other cases the scar tissue around the implant can become hard and painful. This uncomfortable condition, known as capsular contracture, is among the most common reasons for implant removal. Other common problems include rupture, where the saline solution or silicone gel that fills the implant leaks into the surrounding tissues; infection, caused by bacteria becoming rooted in the implant; and rippling, in which the skin over the implant appears irregular.

What’s in ‘vogue’ changes

The allure of the full-breasted figure of the 1950s has given way today to a more natural, athletic and healthy look. Some women find that large, augmented breasts are heavy and unwieldy to manage. “In some cases, women who are unhappy with their implants have them replaced with smaller implants,” says Dr. Chen, “and others revert to their own natural breasts. The aesthetic outcome depends on several factors, including how long the implants were in place. Sometimes a breast lift (or mastoplexy) or fat-grafting procedure may be needed to create attractive breasts”.

In addition to facing medical complications, some women find that their implants look distorted and unnatural, feel hard and uncomfortable, or that they’ve lost all sensation in the breast. “In some cases, the solution is to remove the implant and the entire surrounding capsule and to repair the muscle and skin around it,” says Dr. Chen. “Thankfully, there are ways for women to address problems with breast implants whether it is discomfort or a disappointing aesthetic look. Women today have many options for improving the appearance of their breasts. Sometimes simply removing the implants is the first step”.

About Dr. Constance M. Chen

Constance M. Chen, MD, is a board-certified plastic surgeon in New York City with special expertise in the use of innovative natural techniques to optimize medical and cosmetic outcomes for women undergoing breast reconstruction. She is Clinical Assistant Professor of Surgery (Plastic Surgery) at Weill Cornell Medical College and Clinical Assistant Professor of Surgery (Plastic Surgery) at Tulane University School of Medicine.

Dr. Chen is frequently invited to lecture nationally and internationally on new advancements in breast reconstruction and the surgical treatment of lymphedema. She is the author of three books, five book chapters, and fifty journal articles. She has also won numerous awards for her work in plastic and reconstructive surgery at the local, regional, and national levels.

Dr. Chen has developed a reputation in the community for the personalized attention that she devotes to her patients. She is committed to aesthetic restoration of the breast and body, and enjoys helping her patients achieve overall well-being. At the end of the day, there is nothing more important to her than the joy she hopes to bring to her patients’ lives. Come into the beautiful world of Dr. Constance M. Chen.

Elysium Health Announces Summary Judgment Decision in Case Against ChromaDex in New York – All of ChromaDex’s Claims Against Elysium Health Dismissed

Elysium Health, Inc., a leading life sciences company focused on aging research, is pleased to announce that United States District Court Judge Lewis Liman ordered dismissal of all of ChromaDex’s claims against Elysium Health in a summary judgment decision issued on February 11, 2022, in a false advertising case in the Southern District of New York. This is a significant victory for Elysium Health after also receiving favorable rulings in two other cases with ChromaDex, a patent infringement case in which the U.S. District Court for the District of Delaware invalidated the Dartmouth College patents asserted by ChromaDex, and a nearly five-year litigation in the Central District of California that resulted in a jury rejecting ChromaDex’s trade secret and fiduciary duty claims, offsetting amounts owed by Elysium Health to ChromaDex for a prior order by $625,000 because of ChromaDex’s breach of a pricing agreement, and awarding Elysium Health $1.275 million in damages for ChromaDex’s fraudulent inducement.

What remains in the New York case are several claims, including one for which the judge has already found that ChromaDex made false statements about Elysium Health’s product Basis.

Elysium Health has maintained for years that ChromaDex’s legal accusations were without merit. We are satisfied with Judge Liman’s decision to dismiss the entirety of ChromaDex’s claims against Elysium in New York, and we plan to vigorously pursue all available remedies with respect to those claims that remain.

Eric Marcotulli, CEO Elysium Health

Elysium Health is gratified that the judge has thus far ruled in the company’s favor, and looks forward to a successful conclusion of this case.   

About Elysium Health

Elysium Health’s mission is to solve the biggest challenges in health with science, to help people lead healthier lives. Working directly with the world’s leading scientists and clinicians, Elysium Health™ is committed to translating critical advancements in aging research into health solutions people can access today. Learn more at Elysium Health.

Tired legs? Holy Grail: Clarins Energizing Emulsion

Your lifesaver for tired legs for decades! Clarins Energizing Emulsion is a great product if you have a standing job, are on the road all day, traveling, during or after exercise or if you are pregnant! The added mint essential oil provides an immediate feeling of comfort for lighter legs.

How to use: Use when needed. Always massage in lightly from the feet/ankles upwards (towards the heart). Especially the calves and back of the knees. Clarins Energizing Emulsion can even be applied over tights! And for men with hairy legs, no problem, it’s gone in no time….

Tip: Add a few drops of the Clarins Relax Body Treatment Oil to the Energizing Emulsion for lighter legs and a relaxing moment after a busy day.

Discover Energizing Emulsion. Come into the beautiful world of Clarins.

Elysium Health Announces the Launch of Signal™ for Metabolic Aging

A novel combination of NMN and SIRT3 activators to promote a healthy metabolism by replenishing critical metabolic factors lost with age and activating processes to support healthy mitochondrial function.

Elysium Health, Inc.™, a leading life sciences company developing clinically validated health products based on advancements in aging research, today announced the launch of Signal™, a novel combination of the most direct NAD+ precursor, NMN, and potent SIRT3 activators to promote a healthy metabolism by replenishing critical metabolic factors lost with age and activating processes to support healthy mitochondrial function. Over time, metabolism becomes less efficient as the number and activity of mitochondria in our cells declines. As a result, the creation and utilization of cellular energy, cellular renewal, and the ability of cells to respond to their changing environment are all impacted. Signal targets metabolic aging by supplying declining metabolites and acting to preserve and help generate new mitochondria. 

At Elysium Health, we recognize that aging is a multi-factor problem that requires a multi-factor solution. With each new product we get closer to addressing aging holistically, and to offering our customers the opportunity to truly personalize their Elysium Health regimen. There is preclinical evidence indicating that different NAD+ precursors may exhibit distinct tissue specificity, and clinical evidence demonstrating different activity between NAD+ precursors. While more research is needed to support these findings, it suggests that combining different NAD+ precursors, such as those found in Signal and Elysium Health’s flagship product Basis, may ensure that NAD+ levels are elevated across a broader range of tissues and, accordingly, offer unique benefits to our health.

Eric Marcotulli, CEO Elysium Health

NAD+ (nicotinamide adenine dinucleotide) is a key metabolite, and its levels are closely monitored by the cell in order to tune and balance its metabolic reactions. During calorie restriction, NAD+ levels increase, triggering a specific network of metabolic reactions that have been shown to provide varied health benefits. As we age, levels of NAD+ decline. Signal includes the most direct NAD+ precursor, NMN (nicotinamide mononucleotide), which is efficiently converted to NAD+ by cells.

NAD+ also serves as a coenzyme, or helper molecule, for hundreds of critical enzymes in the cell. This includes the sirtuin family of enzymes. In 2000, Elysium Health co-founder, chief scientist, and director of the Glenn Center for Biology of Aging Research at MIT Dr. Leonard Guarente used preclinical models to show that the beneficial effects of caloric restriction on lifespan and healthspan were mediated by sirtuins and NAD+. Since then, sirtuins have emerged as key regulators of the nutrient-sensitive metabolic regulatory circuit.

Signal is a novel, mitochondria-centric product formulated to counter aging-dependent declines in metabolism by promoting youthful energetics and metabolic efficiency.

Leonard Guarente, Ph.D., Elysium founder, chief scientist, and renowned aging researcher and professor

Three of the seven sirtuins reside in mitochondria. Of these, SIRT3 (sirtuin 3) is the most studied and plays an essential role in maintaining mitochondrial health and metabolic control—from glucose metabolism, ATP production, fatty acid oxidation, and ketone production during fasting, to amino acid cycling. It has even been implicated in nutrient sensing.

As with NAD+, levels of mitochondrial sirtuins also decline with age. Signal contains a proprietary SIRT3 activation complex that consists of two naturally occurring ingredients: honokiol, isolated from the bark of Magnolia Officinalis, and viniferin, derived from grapevines. The SIRT3 activation complex in Signal works synergistically with NMN to activate SIRT3 and to help maintain overall mitochondrial and metabolic health. 

“Mitochondria play a critical role in lifelong health due to their fundamental function creating energy in cells,” said Dr. Guarente. “The mitochondrial sirtuin, SIRT3, is normally activated by a calorie-restricted diet to foster greater energy production and damage protection in these cellular powerhouses. Signal contains natural compounds that activate SIRT3, as well as a unique NAD-booster, NMN, that maintains high activity of all sirtuins, including SIRT3.

“In human studies, NMN has been shown to promote insulin sensitivity in muscle (Imai et al. 2021 Science) as well as increased VO2 max and aerobic capacity (Liao et al. 2021 Journal of the International Society of Sports Nutrition). In aging animals, it has also been shown to improve blood flow and vascular health, and increase endurance (Das et al. 2018 Cell). This novel, mitochondria-centric product is formulated to counter aging-dependent declines in metabolism by promoting youthful energetics and metabolic efficiency”, said Dr. Guarente.

The launch of Signal marks the fifth consumer product for Elysium Health since the brand launched in early 2015. The company is also set to debut a multi-functional, science-first skincare line under a new standalone brand in partnership with Elite World Group later this year. In addition to its consumer businesses, Elysium Health has developed an experimental therapeutic EH301, which showed promise in a pilot study and continues to be studied for the potential treatment of Amyotrophic Lateral Sclerosis (ALS).

About Elysium Health™

Elysium Health’s™ mission is to solve the biggest challenges in health with science, to help people lead healthier lives. Working directly with the world’s leading scientists and clinicians, Elysium Health™ is committed to translating critical advancements in aging research into health solutions people can access today.

Learn more at Elysium Health.

Legendary Designer and Fashion Icon, Iris Apfel, Joins the Bone Health and Osteoporosis Foundation’s Ambassadors Leadership Council

Bone Health and Osteoporosis Foundation Ambassador Iris Apfel (Photo courtesy of Ruvén Afanador for Zenni Eyewear)

The Bone Health and Osteoporosis Foundation (BHOF) today welcomed Iris Apfel to its Ambassadors Leadership Council. Ms. Apfel, renowned for her eclectic sense of style and super-sized, black rimmed specs, is 100 years old and may be the most vibrant and altruistic of BHOF’s Ambassadors. Skilled at making an impact, Ambassadors work to spark positive change in the world of bone health.

I celebrated my centennial last year, but I never really think about my age. Work keeps me feeling young and vibrant. I’m proud to be a BHOF Ambassador to help educate people about taking care of their bone health if they want to lead an active and fulfilling life – at every age.

Iris Apfel

“We are thrilled to have Ms. Apfel as our first Ambassador of 2022! She is the epitome of what we all hope for as we age – being healthy, active, and making the world a little better,” said Claire Gill, CEO, BHOF. “We are excited that Ms. Apfel will help us raise awareness and dispel some big myths, including that only older people need to worry about osteoporosis and breaking bones”.

The statistics on osteoporosis are staggering: approximately 10 million Americans age 50 and above have the disease and another 44 million have low bone density, placing them at an increased risk for bone fractures. Most people are not aware that bone fractures related to osteoporosis are responsible for more hospitalizations than heart attacks, strokes and breast cancer combined.

Ms. Apfel will star in a marketing campaign for BHOF this year to raise awareness about the importance of bone health at every age. For information about the Ambassadors Leadership Council and key facts about bone health, visit BHOF.

We Know Smoking Causes Cancer, But it is Also Harmful to Your Skin

Dermatologist Dr. Suzanne Friedler with Advanced Dermatology Provides Tips on the Skin Risks Associated with Smoking.

Smoking affects nearly every organ in the body and puts your overall health at risk. It damages your heart, your lungs, your bones, even your fertility. What does it do to the largest organ in the body – your skin?

Smoking is related to the development of several skin disorders and if you already have a skin condition, smoking will make it worse. And while it is true that everyone’s skin eventually shows the effects of age, smoking accelerates the development of wrinkles, sagging skin, puffiness under the eyes, uneven complexion, and thinning lips. Along with sun exposure, smoking is a primary culprit in premature aging of the skin.

Dr. Suzanne J. Friedler

Smoking causes premature aging in two key ways. First, the toxins in cigarette smoke destroy collagen and elastin, the fibrous components of skin that give it strength and elasticity. As these building blocks of the skin become progressively damaged, the skin sags and develops deep wrinkles.

The more you smoke, the sooner you’ll see these effects and the longer you smoke, the more pronounced they’ll be. Even exposure to secondhand smoke will cause this damage.

Dr. Suzanne J. Friedler

The second essential effect of smoking on the skin is to deprive it of oxygen and nutrients. Smoking causes narrowing of the blood vessels that deliver these elements that are essential to healthy skin. Their lack contributes to uneven complexion, poor skin tone and the development of a wide array of skin conditions.

Skin cancer: Smokers are at greater risk of developing squamous cell carcinoma, the second most common form of skin cancer. It is thought that tobacco suppresses the immune response that would prevent squamous cells from proliferating on the outermost layer of skin. Squamous cell carcinoma is easily treated when caught early but can metastasize if undetected and can potentially be life-threatening. Smoking is also the primary cause of several types of oral cancer.

Pigmentation: Smoking increases melanin in the skin leading to dark spots particularly on the face and hands. These spots can be caused by sun exposure but research suggests that smokers are more susceptible to them. Stained fingers and nails are also common in smokers.

Psoriasis: Smoking is a risk factor for this chronic inflammatory condition characterized by itchy, scaly patches, usually on the elbows, knees, scalp, hands, and feet. The culprit may be the nicotine in cigarettes which affects the immune system, inflammation, and skin cell growth, all of which contribute to the development of psoriasis.

Wound healing: Narrowing of the blood vessels caused by smoking constricts circulation making it harder for even minor cuts and scrapes to heal and contributing to scarring. Patients are advised to stop smoking before a surgical procedure to reduce the risk of impaired healing of an incision in the skin.

According to the Centers for Disease Control and Prevention, more than 30 million American adults smoke. But more than 50 million Americans have quit smoking. “There are many reasons to quit smoking,” says Dr. Friedler. “Any skin condition you have that is related to smoking will be more manageable when you quit and further damage will be avoided. While not all the damage to your skin will be reversible, there are topical retinoids and vitamin C and E creams that can help and cosmetic procedures like laser skin resurfacing and chemical peels can improve the appearance of the outer layers of skin where damage is most visible. You can quit smoking. Ask your doctor which cessation strategy would be best for you”.

About Dr. Suzanne J. Friedler

Suzanne J. Friedler, M.D. F.A.A.D., is a board-certified fellow of the American Academy of Dermatology, with expertise in many areas of medical and cosmetic dermatology. She has been with Advanced Dermatology PC since 2002.

Come into the beautiful world of Suzanne Friedler, MD.